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Inflammatory bowel diseases 2016;22:207897
Because Retatrutide remains an investigational compound, any mention of an 8mg figure online reflects research reporting rather than an approved prescribing standard
Combined with semaglutide in the BELIEVE trial (results published May 2026), the combination achieved substantial weight loss with about 92% of it coming from fat, and lean mass was largely preserved
In a landmark Phase 2 trial published in the New England Journal of Medicine, participants receiving the 12 mg dose experienced mean weight loss of 24.2% at 48 weeks, significantly exceeding results from earlier GLP-1 or dual-agonist therapies