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"Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians"

J Frailty Aging

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The diagnosis of vitamin B12 deficiency typically relies on low total B12 levels and elevated concentrations of homocysteine (Hcy), as well as levels of transcobalamin-bound B12 (holoTC) and methylmalonic acid (MMA), which serve as functional indicators of cobalamin insufficiency (Carmel and Sarrai, 2006)

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that is essential for nervous system function, red blood cell development, DNA synthesis, energy metabolism, and antioxidant activity