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Positive outcomes were consistent across the evidence base we reviewed, however, some of the included studies showed a potentially significant overlap, which limits the overall level of evidence
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The weight regain pattern after stopping tirzepatide is significant
However, cotadutide demonstrated superior performance in decreasing liver triglyceride levels and ameliorating mitochondrial functional markers in the liver compared to liraglutide, despite comparable reductions in body weight and food intake between the two treatments [43]
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