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doi: 10.1111/bcpt.v130.2 182 ChenYZhaoYMiaoCYangLWangRChenBet al
P53 can inhibit cysteine uptake by downregulating SLC7A11, reducing GPX activity and GSH synthesis and subsequently causing intracellular ROS accumulation and ferroptosis (83)
Canipari R, De Santis L, Cecconi S
However, new targets from detailed molecular mechanistic analyses and improved gene therapy delivery technologies, such as using non-viral, nanoparticle-based DNA delivery mentioned below, provide renewed optimism
A single study also noted reduced levels of Anaerostipes , which belongs to the family of Lachnospiraceae and is also a butyrate producer in the intestines [84]
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