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By activating GIP receptors alongside GLP-1 receptors simultaneously, tirzepatide creates synergistic metabolic effects that exceed what either hormone achieves alone

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Differences in microbiota composition were predictive of glycemic responses to GLP-1RA intake 61 and further work is required to determine factors influencing GLP-1RA-mediated renoprotection which appear to be independent of improvements in glycemic control 62

While these agents demonstrate greater weight loss efficacy, their effects on eating experience and food reward remain incompletely characterised