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Though specific resistance mechanisms were not mentioned in the referenced clinical trial, the renal effects warrant careful consideration in patients with compromised kidney function [84]

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The role of nutrition on thyroid function

If sleep disturbance occurs with evening dosing, switching to morning may help

The following have been shown to shift estrogen metabolism toward the 2-hydroxyestrone pathway[2]: Exercise and weight loss Isoflavones such as soy and flaxseed Omega-3 fatty acids Green tea polyphenol Cruciferous vegetables and broccoli derivatives, including indole-3-carbinol (I3C) and diindolylmethane (DIM, result of I3C after activation by stomach acid) A healthy lifestyle that allows for a normal weight helps to decrease the risk of insulin resistance from metabolic syndrome