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That pressure is what causes the classic symptoms: localized pain, radiating pain down a leg (sciatica) or arm, numbness, tingling, and muscle weakness

Glucolipotoxicity: Fuel Excess and -Cell Dysfunction

163 Due to dysregulation of SIRT1, STAT3, and O-GlcNacylation induce hyaluronic acid storm through activation of HAS2

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doi: 10.3389/fcvm.2025.1574489 Received 10 February 2025 Accepted 03 March 2025 Published 25 March 2025 Volume 12 - 2025 Edited by Ryuichi Morishita, Osaka University, Japan Reviewed by Chieko Mineo, University of Texas Southwestern Medical Center, United States Kimie Tanaka, Juntendo University, Japan Updates Copyright 2025 Jha, Nakano, Itto, Barbeiro, Lupieri, Aikawa and Aikawa