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FDA labeling for stimulants recommends assessing for cardiac disease before starting therapy and monitoring vital signs
J Exp Med 210:225232 Walrafen P, Verdier F, Kadri Z, Chrtien S, Lacombe C, Mayeux P (2005) Both proteasomes and lysosomes degrade the activated erythropoietin receptor
A meta-analysis by Sniderman et al
These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects
Reference Lanot, Zachary, Holder and Meister2001)
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