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When used together for muscle mass, Ipamorelin and CJC-1295 create a synergistic effect

The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses

The good news: most patients report symptom resolution within 2-4 weeks as their body adapts to the medication and weight stabilizes

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Hemoglobin A1c will rise more gradually over subsequent months