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Remaining hurdles to widespread adoption are likely to be addressed in the coming months

Current evidence suggests its safety profile is manageable and consistent with the incretin class, with no major safety barriers identified to date

Patients with obesity only had a higher prevalence of discontinuation versus those with Type 2 diabetes or those with both conditions

Furthermore, the main transcriptional regulator of the enzymes in this pathway, Klf15, was upregulated in the semaglutide-treated samples, and we observed no significant change in Bckdk levels, the main negative regulator of this pathway ( Figure 3C ) 76,77

Too deep reaches muscle tissue, changing the absorption profile