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EVs play a critical role in intercellular communication by transporting bioactive proteins, lipids, and RNAs, making them a valuable source of circulating biomarkers for various diseases [49, 51,52,53]

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A novel therapeutic target for DM are incretin-based therapies, glucagon-like peptide-1 (GLP-1), and gastric-inhibitory-polypeptide (GIP) are released from the gastrointestinal tract (GIT) and act on the beta cell of pancreatic islets by increasing the secretion of insulin

In the gut, saffron regulates the microbiota by decreasing pathogenic species and combating dysbiosis [81]

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