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DPP-4 Inhibitors and BP Regulation: Potential Mechanisms Primary hypertension is a cardiovascular syndrome characterized by elevated BP, and represents the leading cause of cardiovascular disease and stroke and the primary cause of death and disease burden worldwide (24)

Four SNPs were associated with higher obesity risk under heterozygote and dominant models for GSTM1 rs1056806 (C/T), homozygote model for SOD2 rs4880 (A/G), and homozygote and recessive models for GPX1 rs1800668 (A/G)

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Semaglutide activates only the GLP-1 receptor, whereas Tirzepatide is a dual GLP-1/GIP agonist