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Pflipsen MC, Oh RC, Saguil A, Seehusen DA, Seaquist D, Topolski R

Heres the science explained simply in everyday terms: Your cells have an enzyme called NNMT that becomes overactive when youre carrying extra weight (especially in fat tissue)

(Injecting plain water in large volume would cause cells to swell and rupture due to osmotic imbalance, so sterile water is only given after adding an appropriate amount of solute to make it nearly isotonic

This makes degradation undetectable without functional assaysmass spectrometry alone won't catch it