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A double-blind, placebo-controlled trial on CB4211, which is an analog (synthetic version) of MOTS-c, found the compound to be "safe and well tolerated" under a single and multiple ascending dose protocol in adult humans

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Intrahepatic cholangiocarcinoma Expression characteristics of adrenergic receptors in ICC Compared to non-tumor liver tissue, the density of 1- and 2-adrenergic receptors in ICC is significantly reduced

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