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Currently, several pharmaceutical companies are investigating specific SIRT1 activators in Phase I and Phase II trials for the treatment of type II diabetes and obesity (228) to define their utility in the treatment of obesity and metabolic diseases

Baseline and on-treatment measurements would provide evidence of whether oxidative stress is actually elevated and whether intervention helped

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Baseline Evaluation Comprehensive metabolic panel Fasting glucose, insulin, A1C Lipid panel (LDL, HDL, triglycerides), advanced lipid markers if indicated

Phase I and Phase II Detoxification In Phase I , the liver takes a toxin and uses enzymes to break it down