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This approval is a significant decision because people living with excess weight or obesity and established cardiovascular disease and without diabetes have never had an FDA-approved treatment option that lowers weight and reduces the likelihood of another cardiovascular event, said A Michael Lincoff (Cleveland Clinic, Cleveland, USA) and the lead study author of the SELECT outcomes trial

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An additional 5 ml of HBSS was added for a final collagenase concentration of 1%