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Stop treatment and contact a healthcare professional if you experience: Significant swelling of the hands, feet, or face Chest pain or shortness of breath Sudden vision changes Signs of an allergic reaction, such as rash or throat swelling Noticeable mood changes or depressive symptoms Why Do Side Effects Happen

This tissue becomes a potent source of adipokines (e.g., leptin, resistin, visfatin), cytokines, and prostaglandins that act locally and systemically to exacerbate joint inflammation, cartilage catabolism, and pain perception (Braun et al., 2022

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Department of Human Biology, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa II PhD