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Clinical experience shows that separating semaglutide injection from oral levothyroxine by at least 30 minutesideally taking levothyroxine on an empty stomach in the morning and semaglutide laterminimizes any absorption concerns

PMID: 29097493

The two forms carry different approved indications, different dosage strengths, different administration requirements and different supporting trials, and the choice between them is a clinical conversation rather than a preference setting

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GLP-1 receptor agonists such as semaglutide are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or MEN 2, and should be avoided during pregnancy and breastfeeding