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6 The impact of existing treatment strategies on immune-inflammatory interactions Growing evidence indicates that immune-inflammatory dysregulation plays a pivotal role in the pathogenesis of varicocele-related complications, including male infertility and erectile dysfunction (184)

Cartilage-binding autoantibodies and inflammatory cytokines induce DRG neuron hyperexcitability and sensitization to painful stimuli when injected in experimental animals 4,5,6

Funding Funding for this review, including the journals Rapid Service Fee was funded by Nono Nordisk

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