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It's been studied in cell cultures, animal models, and human clinical trials

doi: 10.1515/cclm.2002.078

For example, in the STEP 1 trial , patients taking semaglutide lost an average of 14.9% of their body weight over 68 weeks , compared with just 2.4% in the placebo group (NEJM study)

do not apply on other parts of the body