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Carnitine uptake by the liver depends on relatively high carnitine concentration in the blood, since carnitine enters the liver through OCTN2 (organic cation transporter 2), a carrier with high Km (Michaelis-Menten constant) for carnitine (Km = 5.6 mM: Christiansen and Bremer, 1976 ), thus the liver takes carnitine from the blood when its concentration is significantly rised

Eating smaller, lower-fat meals

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The PIONEER-6 trial suggests cardiovascular benefit of oral semaglutide in patients with diabetes compared to placebo

GLP-1 receptor agonists would not replace these evidence-based interventions, though they might be used concurrently to manage associated metabolic complications such as diabetes, if clinically appropriate and under specialist guidance