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Rapid weight loss is a known risk factor for gallstone formation, as it alters the balance of bile components

These changes can impact both mucosal integrity and immune tolerance, leading to greater gut permeability, which has been reported to precede clinical onset of T1D (131)

In addition, high-salt diets have led to histologically detectable intestinal inflammation in mice models, as confirmed by goblet cell depletion, ulceration, erosion, and destruction of the mucosal layer (Aguiar et al