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Jia D, Duan F, Peng P, Sun L, Liu X, Wang L, Wu W, Ruan Y, Gu J

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187,500,505,506 The increased activity and expression of CD38 following aging is responsible for the age-associated decrease in NAD + level and defective mitochondrial function, which is at least partially regulated by the NAD + /SIRT3 signaling pathway