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In a clinical sample of 116 participants [30], subjects with Major Depressive Disorder (MDD) showed significantly lower C2 levels than healthy controls

A more recent study showed that butyrate levels in PD patients increased due to the production of SCFA after being treated orally with resistant starch, along with improvements in non-motor symptoms ( 2.2.5.3 FMT Sampson et al

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The topical version, we have more glue than in there, in fact, but we have controlled the penetration of it, so it's just to keep it skin specific