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Nonetheless, there is a need for novel in vitro models alongside the use of human and animal in vivo techniques to assess permeability (75)

In Graves disease, the immune system mistakenly creates antibodies that stimulate the thyroid gland to develop an excessive quantity of thyroid hormones, primarily thyroxine (T4) & triiodothyronine (T3)

MAT1 KO hepatocytes can also be detected with reduced methylation/CYP2E1 ratio, reduced mitochondrial membrane potential, increased ROS content, and are sensitive to ethanol and TNF--induced mitochondrial dysfunction

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If this doesnt give a clear result, other tests, like an array comparative genomic hybridization (aCGH), might be needed