The 0.3 mg/kg/day was selected based on prior studies in DIO mice ( n = 6 per group) [29]
Drug Name: Semaglutide Manufacturer: Novo Nordisk Type: GLP-1 agonist Brand Names: Ozempic = Type 2 Diabetes, weekly injection (approved December, 2017) Rebylsus = Type 2 Diabetes, daily pill (approved September, 2019) Wegovy = Weight Loss, weekly injection (approved June, 2021) Drug Name: Tirzepatide Manufacturer: Eli Lilly Type: GLP-1/GIP co-agonist Brand Names: Mounjaro = Type 2 Diabetes, weekly injection (approved May, 2022) Zepbound = Weight Loss Application, weekly injection (approved November, 2023) (No pill form exists as of this writing) The short story is that both drugs were originally introduced as effective Type 2 Diabetes medications
That's considerably higher than the price-to-earnings (PE) ratio of the S&P 500 as a whole, which has a trailing P/E of about 32 and a forward P/E of around 20
However, now that semaglutide is no longer on the list, that authorization is essentially revoked
The upper thigh also has a lower concentration of nerve endings compared to the abdomen, which many patients report as more comfortable for weekly injections