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In all three studies, adults with obesity or overweight with at least one weight-related comorbidity were randomly assigned to once-weekly subcutaneous tirzepatide or placebo for 72 weeks

Poor sleep, which can increase cravings and lower impulse control

Or they may be acting on the vagus nerve, which connects the gut to the brain

Glucagon receptor (GCG) activation adds: Effects: Increases energy expenditure Promotes fat oxidation (burning fat for fuel) Signals satiety through brain-gut communication May enhance liver fat reduction Potentially greater effects on body composition The glucagon component matters: Research shows that glucagon signaling through the vagal nerve creates feelings of fullness, and glucagon receptor activation in the liver stimulates FGF21 secretiona hormone that helps burn fat without necessarily reducing food intake