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Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years

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Additional studies have identified the biochemical pathways through which PKC regulates ciliary function, particularly in response to oxidative stress, aging, and alcohol consumption, all of which contribute to slowing ciliary beat frequency (7678)