Safety and Side Effects Like all therapies, GLP-1 medications can have side effects most commonly digestive symptoms such as nausea, vomiting, or constipation as the body adjusts
M., Lancho, C., et al
sometimes increases in HDL Liver : Improvements in fatty liver disease (reduced liver fat, improved liver enzymes) Cardiovascular Improvements : Blood Pressure : Significant reductions in systolic and diastolic blood pressure Cardiovascular Events : According to SELECT trial (semaglutide), 20% reduction in major cardiovascular events (heart attack, stroke, cardiovascular death) Heart Function : Improvements in cardiac structure and function markers Physical Function Improvements : Mobility : Improved ability to walk, climb stairs, engage in physical activities Joint Pain : Reduced knee, hip, and back pain from decreased weight-bearing stress Sleep : Improvements in sleep quality
In trials of tirzepatide, the active ingredient in Zepbound, patients receiving the highest dose lost roughly 20%, on average
Ghosal S, Datta D, Sinha B