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Its activity can be reduced in physiological conditions, it is susceptible to proteolytic degradation, and it can exhibit cytotoxicity at high concentrations

They're tools for fundamentally different research questions

Early Life Oxidative Stress and Long-Lasting Cardiovascular Effects on Offspring Conceived by Assisted Reproductive Technologies: A Review

"By treatment of obesity, you are reducing hospitalizations, illnesses, preventing chronic diseases like Type 2 diabetes, stroke, heart attacks, all of these that actually end up costing the state more money downstream," she said

Independent of loss of kidney function, a rise in BUN may also occur as a result of hypercatabolism from the excess breakdown of amino acids