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The latter also acts as a coreceptor of the phosphaturic hormone fibroblast-growth factor 23 in the proximal tubule

Overuse may increase the risk of: Redness and irritation Dryness and peeling Increased skin sensitivity Uneven skin tone from irritation A rare condition called ochronosis, associated with prolonged use Ochronosis is uncommon, but it is one reason experts encourage time-limited use and medical supervision when possible

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[43] Although not studied, the concomitant use of ethanol and phentermine may result in an adverse reaction and should be avoided

The generation of OH provokes the oxidation of PUFAs and thereby initiates the cascade leading to ferroptosis