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The rich lymphatic and vascular network of the oral cavity facilitates early hematogenous and lymphatic spread to regional lymph nodes, lungs, liver, and brain, contributing to the poor prognosis and highlighting the need for targeted therapeutic approaches addressing the unique molecular characteristics of mucosal melanomas [13]

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Mechanistically, hypervolaemia increases the haemodynamic workload to the filtration surface present, for example, causing glomerular hyperfiltration that imposes shear stress to the glomerular filtration barrier 86

Evaluate diet and activity patterns before considering dose increases

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