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Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

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Individuals with Gastrointestinal Disorders Conditions such as Crohns disease, celiac disease, or those who have undergone weight loss surgery can affect the bodys ability to absorb B12

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Symptoms of vitamin B12 and folate deficiency include extreme tiredness, shortness of breath, palpitations and muscle weakness