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10.4103/0973-7847.70902 165 LopezS

GLP-1, but not metformin, significantly ameliorated AMPK activator- or MG-induced cell death and apoptosis We administered different concentrations of AMPK activator, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR, 0.5, 1, 1.5, and 2 mM) to RINm5F cells and then incubated for 2, 4, 6, 17, and 24 h, respectively

It reflects a strategic shift toward: Better patient convenience and adherence Expanded market accessibility Greater competition in the obesity segment New lifecycle management opportunities Stronger focus on patient-centric innovation As pharmaceutical professionals, we should not only monitor **new drug approvals** but also understand how they reshape disease management, patient behavior, and market strategy