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Intranasal DSIP administration accelerated motor function recovery in rats after focal stroke, suggesting neuroprotective effects that extend well beyond sleep regulation

However, therapeutic strategies are still debated

Cardiotoxicity was induced by administration of a barium chloride solution (10 mg/kg b.w.), desipramine (10 mg/kg), digitalis (total dose 6.5 mg/kg) and isoprenaline (15 mg/kg) through a jugular venous cannula