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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

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What This Means for Patients The progression from single agonist (semaglutide) to dual agonist (tirzepatide) to triple agonist (retatrutide) demonstrates that targeting multiple complementary pathways can produce incrementally better outcomes

Moreover, SCFAs were shown to augment the production of leptin which, as discussed above, was found to be decreased in disorders marked by impulsivity, thus linking SCFAs with psychiatric conditions (169)

Zhdanova, I