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Interestingly, the combined treatment of epalrestat with N -Acetylcysteine (NAC), an anti-oxidant, to AIA rats dramatically suppressed the production of 4-HNE, MDA and inflammatory cytokines, and significantly improved the arthritic condition

Ingredients: Acetyl L-Carnitine (from acetyl L-carnitine HCI) Other ingredients: Hypromellose (vegetable capsule) microcrystalline cellulose (plant fiber), magnesium stearate, silica

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instead, its proposed mechanism involves multiple downstream effects mediated by copper coordination chemistry and tripeptide-specific interactions with various proteins