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The core feature of cleavable linkers is the presence of chemical structures that respond to specific biological conditions, such as peptide bonds (e.g., Val-Cit sequence) recognized by lysosomal proteases like Cathepsin B, hydrazone bonds sensitive to acidic environments, and disulfide bonds that can be reduced under reductive conditions

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Moreover, limiting exposure to environmental toxinslike pollutants, smoke, and alcoholhelps conserve glutathione, which is constantly used up in detoxifying these harmful substances