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Adipose tissue, particularly visceral fat, is metabolically active and secretes pro-inflammatory adipokines

(2010) demonstrated that AS-IV at 50 and 100 mg/mL significantly improved the function of homocysteine-induced human umbilical vein endothelial cells by reducing reactive oxygen species (ROS) accumulation and increasing superoxide dismutase (SOD) activity (Qiu et al., 2010)

Mitochondrial dynamics shift, affecting fission-fusion balance and uncoupling protein expression[9]

Clinically, susceptibility-weighted imaging (SWI imaging) was used to evaluate iron deposition in the basal ganglia of PD patients, and it was found that iron deposition in the basal ganglia of PD patients would increase with the progression of the disease [103]

Usually decreases in frequency after 4 to 6 weeks at a stable dose