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This depletion can lead to anemia, and also an increased risk that their breastfed infants become vitamin deficient

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

A 10 mg vial reconstituted with bacteriostatic water yields about 10 mg/mL

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Whether it produces meaningfully better outcomes than once-daily dosing in humans remains unknown