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These endocannabinoids primarily target CB1 and CB2 receptors found in microglia, glial cells, and neurons (54)

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MALE FERTILITY AND SPERMATOGENESIS Hypogonadotropic Hypogonadism: Steroidogenesis Restoration Serum testosterone: increase from 200 ng/dL above baseline Primary failure: no response (Leydig cell damage) Secondary failure: present response but low baseline Applications: Differentiation between primary and secondary hypogonadism Pre-pubertal Leydig cell reserve evaluation Treatment response prediction 5

Friedmann Angeli JP, Conrad M