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Additionally, Atg5 knockout affects steroid hormone synthesis due to cholesterol deficiency caused by impaired autophagy (Texada et al., 2019)

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Indeed, the presence of sarcopenia and obesity, as well as SO with its dual impact, contributes substantially to national and global healthcare expenditures and serves as a prognostic factor for the growing burden on public health [5, 6]

Methionine is the primary target