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doi:10.3390/cells13010065

However, the patients enrolled in EMPA-REG had little CKD at the start of the trial

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Further applying Seahorse extracellular flux assays, studies have demonstrated that the heightened mitochondrial respiration observed in CF cell lines, including HBE cells expressing CFTR F508del/F508del , can be remarkably normalized by triple CFTR modulator therapy through mechanisms involving calcium (Jarosz-Griffiths et al., 2024)