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doi: 10.1038/s41419-022-04866-x 143

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the goal is to circumvent chemoresistance by using multiple drugs with different anticancer mechanisms (Doroshow 2017)

Mitochondrial autophagy (mitophagy) is critical for the clearance of damaged mitochondria, and it is primarily regulated by two proteins, PTEN-induced putative kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin