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JanuchowskiRWojtowiczKSterzy?skaKSosi?skaPAndrzejewskaMZawieruchaPet al

Those with hepatic impairment, thyroid cancer risk, pancreatitis history, or uncontrolled diabetes may require branded alternatives with expanded clinical data

Pricing for orforglipron has not been announced since it is not yet approved

This observation aligns also with a generally lower correlation in gene expression in hypothalamic neurons of both mice treated with the GIPR antagonist or acyl-GLP-1, and further in mice treated with acyl-GIP or MAR709 (Extended Data Fig