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Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione

In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF

But it is not strictly necessary

The 500 Dalton rule (molecular weight below 500 Da correlates with percutaneous absorption) is a necessary but not sufficient condition, not a guarantee

They further characterized formononetin absorption, noting there was no significant difference between permeability in the A to B direction and that in the B to A direction, and transportation of formononetin across intestinal epithelial cells was mainly through passive diffusion [126]