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The longer duration (68 weeks vs 48 weeks in Phase 2) allowed assessment of sustained efficacy

Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y et al (2018) Protective effect of sex hormone-binding globulin against metabolic syndrome: in vitro evidence showing anti-inflammatory and lipolytic effects on adipocytes and macrophages

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A healthcare provider should review individual medical history before starting treatment

The GLP-1 receptor density varies between individuals, and some require more semaglutide to achieve the appetite suppression threshold that drives meaningful caloric reduction