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Ecotoxicol Environ Saf 200:110732

Pharmacodynamic monitoring and biomarker-guided selection should verify on-lesion activity while safeguarding marrow and mitochondrial function

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Short-term GLP-1R/GCGR dual agonism results in normal insulin secretory capacity during hyperglycemic clamp in DIO mice Having assessed insulin sensitivity using the hyperinsulinemic euglycemic clamp, we next sought to examine the impact of cotadutide on insulin secretory capacity and -cell function in response to hyperglycemia