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Nuclear import of Insulin-like Growth Factor-binding Protein-3 and -5 is mediated by the importin

Quick-Reference DDI Summary Table | Co-administered Drug | GLP-1 RA Effect | Clinical Action | |---|---|---| | Insulin (basal) | Additive hypoglycemia | Reduce insulin 20% to 40% at initiation | | Sulfonylurea | Additive hypoglycemia | Halve the dose at initiation | | Warfarin | Possible INR increase | Check INR at 2 to 4 weeks

Nature (2019) 569(7754):738

At the very least, they should pay attention to the advice given in the article they cite in their report's footnote 15, which expressly states: "The use of breed-specific VHS values is needed for the VHS method to have a high specificity for normal heart size." We would prefer using a patient-specific VHS value, rather than just breed-specific, but either one is better than a reckless, species-wide "median" VHS value