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Similar content being viewed by others Introduction Proton pump inhibitors (PPIs) are a class of drugs that specifically block the H + /K + ATPase enzyme (proton pump) located on the apical membrane of gastric parietal cells, thereby inhibiting gastric acid secretion

Treatment will be deemed to have failed in these patients, and they will be further studied and treated outside the trial according to normal clinical practice

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An alternative starting protocol uses 1mg for the first four weeks before moving to 2mg, then following the standard escalation from there